Product Name :
YES1 Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
c Yes antibody Cellular Yes 1 protein antibody Cellular Yes1 protein antibody HsT441 antibody P61 YES antibody p61-Yes antibody Proto oncogene tyrosine protein kinase YES antibody Proto-oncogene c-Yes antibody Tyrosine-protein kinase Yes antibody v yes 1 Yamaguchi sarcoma viral oncogene homolog 1 antibody 展开
Function :
Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis.
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
KLH conjugated synthetic peptide derived from human YES1 441-541/541
Species reactivity:
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Guinea pig
Verify application:
WB, ELISA, IHC-P, IF
Coupling :
unconjugated
Clone number:
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.Buy56946-65-7 The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃.Formula of 127273-06-7 When reconstituted in sterile pH 7.PMID:33664458 4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.
Storage buffer solution:
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
60 KDa
Positive control :
Expressed in the epithelial cells of renal proximal tubules and stomach as well as hematopoietic cells in the bone marrow and spleen in the fetal tissues. In adult, expressed in epithelial cells of the renal proximal tubules and present in keratinocytes in the basal epidermal layer of epidermis.