Product Name :
Phospho-SMC1 (S957) Recombinant Rabbit Monoclonal Antibody [SC65-03]
Predicted band size :
144 kDa
Observed band size :
150 kDa
Synonyms:
CDLS2 antibody DKFZp686L19178 antibody DXhXs423e antibody DXS423E antibody KIAA0178 antibody MGC138332 antibody OTTHUMP00000061876 antibody RP6 29D12.1 antibody SB1.8 antibody Segregation of mitotic chromosomes 1 antibody 展开
Function :
The SMC (structural maintenance of chromosomes) family of proteins form heterodimeric complexes that modulate sister chromatid cohesion and chromosome condensation for mitosis. The two distinct classes of SMC protein complexes are comprised of SMC1 (also designated SB1.8) with SMC3 (also designated HCAP for human chromosome-associated protein and Bamacan for the secreted proteoglycan), and SMC2 (also designated hCAP-E) with SMC4 (also designated hCAP-C). The SMC1/SMC3 complex is required for metaphase progression in mitotic cells and functions independently of the SMC2/SMC4 complex during the cell cycle. SMC1 is ubiqitiously expressed in various human tissues, including thymus, testis and colon. SMC3 is expressed as a nuclear protein in the colon, but can also occur as a secreted proteoglycan expressed in testis and brain.1301214-72-1 web The secreted proteoglycan contains several glycosylation sites and is thought to play a role in basement membrane physiology.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Synthetic phospho-peptide corresponding to residues surrounding Ser957 of Human SMC1 aa 945-980 / 1233.
Species reactivity:
Human
Verify application:
WB, IHC-P, IF-Cell
Coupling :
unconjugated
Clone number:
SC65-03
RRID:
AB_3073459
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.Formula of 4-(Dimethylamino)but-2-ynoic acid Aliquot store at -20℃ or -80℃.PMID:33474995 Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 144 kDa
Positive control :
HeLa cell lysate, HeLa treated with UV then recovery 30 minutes cell lysate, HeLa cells treated with UV then recovery 30 minutes, human tonsil tissue, human lung adenocarcinoma tissue, human breast carcinoma tissue.