27 (3.0) 9 (four.five) 20 (six.two) six (21.4) 2 (20.0) five (7.9) 4 (9.1) 12 (four.three) 2 (13.three) 1.6 (4.11e13) 1.six (7.7e-06) 1.9 (0.000352) 1.3 (6.35e08) 3.5 (0.00099) three.6 (0.000814) four.two (0.00132) 1.4 (0.0102) 1.five (0.000332) 1.9 (0.0041) 1.six (0.0315) three.3 (0.0383) five.5 (0.0256) 2.five (0.0296) two.7 (0.0423) 1.6 (0.0404) 4.three (0.0403) 3.3 (0.00106) 9.two (0.00292) 3.eight (0.0141) 3.2 (0.0274) 5.6 (0.0161) three.six (0.0273) 7 (6.7) 5 (11.9) six (7.six) 6.6 (0.0277) five.0 (0.0383) three.0 (0.0402) five (six.five) 1.four (0.0415) 7.4 (0.0441) 83 (15.5) 4 (80.0) five (71.four) 6 (54.five) 17 (36.2) 46 (23.two) 172 (15.2) 30 (25.0) 44 (19.six) four (one hundred.0) 7 (50.0) 26 (23.6) 18 (25.4) 18 (25.0) 12 (36.4) 83 (15.5) 302 (16.9) 130 (17.7) 62 (20.three) 461 (14.1) 16 (38.1) 16 (39.0) 12 (46.two) 145 (14.eight) 143 (16.1) 42 (20.9) 56 (17.two) 10 (35.7) 6 (60.0) 17 (27.0) 13 (29.5) 49 (17.five) 7 (46.7) 17 (36.2) 5 (100.0) 10 (41.7) RA vs OA or NL or OA+NL

27 (three.0) 9 (four.5) 20 (6.2) 6 (21.four) 2 (20.0) five (7.9) 4 (9.1) 12 (four.3) 2 (13.3) 1.six (4.11e13) 1.6 (7.7e-06) 1.9 (0.000352) 1.3 (six.35e08) three.5 (0.00099) 3.6 (0.000814) 4.two (0.00132) 1.4 (0.0102) 1.five (0.000332) 1.9 (0.0041) 1.six (0.0315) three.three (0.0383) 5.five (0.0256) two.5 (0.0296) 2.7 (0.0423) 1.6 (0.0404) four.3 (0.0403) three.three (0.00106) 9.2 (0.00292) three.8 (0.0141) 3.two (0.0274) five.6 (0.0161) three.6 (0.0273) 7 (six.7) five (11.9) six (7.six) 6.six (0.0277) 5.0 (0.0383) 3.0 (0.0402) five (6.5) 1.4 (0.0415) 7.four (0.0441) 83 (15.5) four (80.0) five (71.four) 6 (54.5) 17 (36.2) 46 (23.two) 172 (15.two) 30 (25.0) 44 (19.six) 4 (one hundred.0) 7 (50.0) 26 (23.6) 18 (25.4) 18 (25.0) 12 (36.4) 83 (15.five) 302 (16.9) 130 (17.7) 62 (20.3) 461 (14.1) 16 (38.1) 16 (39.0) 12 (46.2) 145 (14.8) 143 (16.1) 42 (20.9) 56 (17.2) ten (35.7) six (60.0) 17 (27.0) 13 (29.five) 49 (17.5) 7 (46.7) 17 (36.2) five (one hundred.0) 10 (41.7) RA vs OA or NL or OA+NL RA vs OA+NL EF # of DMGs EF (q-value) # of DMGs (q-value) ( ) ( ) 3.five (0.000494) two.two (7.07e05) 1.four (0.000717) 2.3 (0.00282) 1.eight (0.00821) 9.1 (0.02) 4.5 (0.0346) 2.1 (0.0176) two.3 (0.0443) two.three (0.0481) three.three (0.0173) 1.four (0.0425) 1.six (two.4e-13) 1.6 (two.91e06) 1.9 (0.000153) 1.three (four.6e-08) three.5 (0.00133) three.5 (0.00104) four.two (0.00175) 1.four (0.00501) 1.five (0.000606) 1.9 (0.00594) 1.six (0.019) three.2 (0.0439) five.5 (0.0292) two.5 (0.0352) two.7 (0.0487) 1.six (0.0497) four.2 (0.0456) three.3 (0.00145) 9.1 (0.0036) three.eight (0.0172) 2.two (0.0177) two.8 (0.0383) two.three (0.0306) 6.5 (0.0313) five.0 (0.0433) 2.2 (0.0448) 1.four (0.0437) 7.3 (0.0493) 18 (38.three) 48 (24.2) 174 (15.four) 30 (25.0) 45 (20.1) four (100.0) 7 (50.0) 26 (23.six) 18 (25.4) 18 (25.0) 12 (36.four) 84 (15.7) 306 (17.2) 133 (18.1) 64 (21.0) 467 (14.three) 16 (38.1) 16 (39.0) 12 (46.2) 149 (15.2) 143 (16.1) 42 (20.9) 58 (17.8) 10 (35.7) 6 (60.0) 17 (27.0) 13 (29.five) 49 (17.5) 7 (46.7) 17 (36.two) five (one hundred.0) 10 (41.7) 25 (24.0) 13 (31.0) 20 (25.3) 5 (71.four) 6 (54.5) 19 (24.7) 84 (15.7) 4 (80.0) 9.0 (0.000111) three.three (0.00287) 1.5 (0.0263) two.3 (0.0441) 2.three (0.0301) 23.5 (0.0176) 20.1 (9.47e05) two.6 (0.0418) 3.three (0.0375) three.three (0.038) 9 (19.1) 14 (7.1) 37 (three.3) 6 (five.0) 11 (4.9) two (50.0) six (42.9) six (five.five) 5 (7.0) five (6.9)Whitaker et al. Genome Medicine 2013, five:40 http://genomemedicine/content/5/4/Page 7 ofTable 3 Gene ontology terms that happen to be enriched in two or much more sets of genes (Continued)troponin complicated phosphatase binding CC MF five.7 (0.0495) 5.4-(Difluoromethyl)-3-fluorobenzoic acid custom synthesis 7 (0.2-(Trifluoromethyl)isonicotinic acid custom synthesis 0495) 5 (62.PMID:33527855 five) five (62.5) 5.7 (0.0442) five.7 (0.0442) five (62.five) 5 (62.five)GO categories which can be considerably enriched (q 0.05) throughout three comparisons are shown. Twelve pathways specifically relevant to RA are placed in the top part of the table whilst other pathways are show at the bottom. Inside every section, the number of significant comparisons orders the pathways. If several GO categories are significantly enriched within the very same number of comparison then an typical q values is used for ordering. Only GO categories discovered as significantly enriched in 3 or far more comparisons are shown. # denotes the number of DMGs in the chosen pathway. The GO category `positive regulation of granulocyte macrophage colonystimulating aspect production’ is abbreviated to `PR of GMSFP’ and category `regulation of fibroblast development aspect receptor signaling pathway’ is abbreviated to `fibroblast development factor receptor signaling’. The GO sorts stand for: BP: biological process; CC: cellular component; MF: molecular function.pathway (see Figure five) is 1.89-fold enriched (P = 0.0042 and q = 0.0377) with 19 out of 92 genes labeled as DMGs within the union set. Certain KEGG pathways.