Product Name :
2-Methoxyestradiol (CAS 362-07-2)
Synonym :
Panzem; 2-ME
Application :
2-Methoxyestradiol is a disruptor of microtubule function and HIF-1 inhibitor
CAS:
362-07-2
Purity:
≥95%
Molecular Weight:
302.4
Formula :
C19H26O3
Physical state:
Solid
solubility :
Soluble in DMSO (10 mg/mL), ethanol (10 mg/mL), chloroform, ethanol (1 mg/ml), and 1:1DMF:PBS(pH7.7-Bromo-4-chloroisoindolin-1-one uses 2) (0.5 mg/ml). Insoluble in water.
Shipping Condition :
Store at room temperature
Melting point:
189-190° C
SMILES:
C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=CC(=C(C=C34)OC)O
References:
and suppresses growth of lesions in a mouse model of endometriosis. | Becker, CM., et al. 2008. Am J Pathol. 172: 534-44. PMID: 18202195Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia. | Kanasaki, K., et al. 2008. Nature. 453: 1117-21. PMID: 18469803New Insight into 2-Methoxyestradiol- a Possible Physiological Link between Neurodegeneration and Cancer Cell Death.1316852-65-9 uses | Gorska, M.PMID:33565330 , et al. 2016. Curr Med Chem. 23: 1513-27. PMID: 26980569The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth. | Fotsis, T., et al. 1994. Nature. 368: 237-9. PMID: 75117982-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site. | D′Amato, RJ., et al. 1994. Proc Natl Acad Sci U S A. 91: 3964-8. PMID: 8171020Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol. | Klauber, N., et al. 1997. Cancer Res. 57: 81-6. PMID: 8988045